UNIVERSITY OF CALIFORNIA, IRVINE
Grant: $382,396 - National Institutes of Health - May. 29, 2009
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Award Description: Multiple Sclerosis is an autoimmune disease resulting from complex interactions between genetic background of the individual and his/her environment. Our combined data suggests that genetic deficiency in a pathway that controls the addition of specific sugars to proteins (i.e. protein glycosylation) leads to immune hyperactivity and promotes autoimmunity in mice and humans. Metabolically supplementing the pathway with an simple sugar suppresses immune hyperactivity and development of autoimmunity, suggesting human disease may be treated/prevented with metabolic therapy.
Project Description: Multiple Sclerosis is an autoimmune disease resulting from complex interactions between genetic background of the individual and his/her environment. Our combined data suggests that genetic deficiency in a pathway that controls the addition of specific sugars to proteins (i.e. protein glycosylation) leads to immune hyperactivity and promotes autoimmunity in mice and humans. Metabolically supplementing the pathway with an simple sugar suppresses immune hyperactivity and development of autoimmunity, suggesting human disease may be treated/prevented with metabolic therapy.
Jobs Summary: Created: Graduate Research Assistant Retained: Senior Resarcher Postdoctoral/Associate Researcher (2) (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on May. 29, 2009. Help expand these official descriptions using the wiki below.
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