Grant: $256,302 - National Institutes of Health - May. 15, 2009
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Award Description: Central nervous system (CNS) diseases and disorders represent the largest and fastest growing area of unmet medical need. Over 1.5 billion people worldwide, including over 100 million people in the US, suffer from CNS diseases or disorders. This project is aimed at finding new ways to get therapeutic drugs to CNS more effectively, more safely, and more conveniently. It is hypothesized that dendrimer nanoparticles carrying brainspecific ligand and a high payload of CNS drugs will cross the BBB in significant amounts via transcytosis. It is further hypothesized that brain-targeted dendrimer nanoparticles can cross the buccal membrane to get into the systemic circulation. We are developing a novel brain-targeted nanomedicine based on dendrimers to deliver drugs to the brain across the blood-brain barrier (BBB) selectively and collectively, thus improving therapeutic effectiveness and reducing side effects. We are also exploring buccal administration for systemic delivery of the proposed nanomedicine to reduce treatment cost and societal burden, increase patient compliance as well as improve the quality of the overall treatment.
Project Description: Progress is being made towards all aspects of the project as described in the Award Description field
Jobs Summary: 1 FTE research assistant in the PI lab 0.6 FTE research assistant in the subawardee lab 0.1 FTE hourly worker in the subawardee lab (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on May. 15, 2009. Help expand these official descriptions using the wiki below.
Funds from this award have been disbursed to sub-grantees. Click here to see a list of sub-grantees.