Grant: $60,633 - National Institutes of Health - May. 15, 2009
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Award Description: Our primary aim is to assess the association of mtDNA polymorphisms and heteroplasmy with active energy expenditure and resting metabolic rate in the elderly. We will carry out our primary aim in a test of healthy samples from the Health, Aging and Body Composition (Health ABC) Study cohort. Active energy expenditure and resting metabolic rate were measured in 1998-1999 in 302 high-functioning, community-dwelling older adults (aged 70-82 years). We will use the recently developed Affymetrix Mitochondrial Resequencing Array v2.0 (MitoChip) to sequence the entire mtDNA genome of 100 low energy 100 high energy women and men. The results of this study may directly link mtDNA mutations with energy expenditure and metabolic rate in the elderly and provide a mechanism by which specific mtDNA mutational events contribute to bioenergenic decline and subsequent mortality. Identifying genetic variants that influence energy expenditure and metabolic rate could eventually lead to interventions that prolong the productive and healthy years of human life.
Project Description: Due to a cut in the budget the number of samples we will be able to sequence has been reduced. To date we have identified the appropriate samples that will allow us to carry out the main aim of the study under the constraints of the grant as funded. The platelet samples being used for this study have been identified and shipped from the storage facility to California Pacific Medical Center for mtDNA extraction.
Jobs Summary: Jobs retained: Gregory Tranah, PI of the project, is being directly supported by the funding from this project. (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on May. 15, 2009. Help expand these official descriptions using the wiki below.