Grant: $77,500 - National Institutes of Health - May. 15, 2009
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Award Description: Small Research Grants: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable.
Project Description: Behavioral Feedback and Neuronal Lifespan The aim of this project is to identify behavioral factors that impact neuron cell death in populations of neurons that are normally replaced throughout adulthood. Specifically, we will determine whether aberrant sensorimotor feedback triggers neuron cell death in the motor pathway producing the behavior. We will assess cell death in cohorts of neurons of different ages using immunocytochemistry to label dying cells, neuron-specific markers, and markers of cell birthdate. Different responses among neurons of different age groups will provide the bassis for subsequent investigation of the mechanisms by which feedback-induced neuron death may occur. We expect to discover a role for the quality of behavioral feedback in regulating neuronal lifespan in adult-formed neurons. The expected translation of this information is its application in designating therapeutic conditions that encourage and maintain healthy neuronal replacement in the human brain as well as in developing treatments for individuals with increased neuron cell death due to illness or injury.
Project Status: Less Than 50% Completed
This award's data was last updated on May. 15, 2009. Help expand these official descriptions using the wiki below.