Grant: $369,250 - National Institutes of Health - Jul. 17, 2009
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Award Description: Characterization of TGR5-D2-WSB1 pathway - testing the hypothesis that TGR5 and WSB1 regulation of D2 activity and thyroid hormone activation is a key pathway involved in the control of energy homeostasis. Generating genetically engineered mouse models (GEMMs) with either germ line or spatially and temporally-controlled TGR5 and WSB1 deficiency has allowed us to test these hypothesis. All animal models porposed have been developed and are now undergoing phenotypic characetrization. There physiological data will be combined with in-depth cellular and molecular profiling, enabling us: 1) to reconstruct the networks governed by TGR5-D2-WSB1 signaling; 2) to determine the importance of localized thyroid hormone production in metabolic homeostasis; and 3) to validate modulation of TGR5-D2-WSB1 signaling as a strategy to prevent and combat metabolic disease.
Project Description: This award was recently received. Minimal activity has occurred at this time as we begin obtain approvals and training required for this project.
Jobs Summary: Prime recipient retained a Research Associate. (Total jobs reported: 1)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 17, 2009. Help expand these official descriptions using the wiki below.