Grant: $547,592 - National Institutes of Health - Sep. 24, 2009
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Award Description: DESCRIPTION: Current methods for measuring dietary intake in free-living people typically result in an average under- estimation of energy intake (EI) of 10-50%. Data are suggestive, but not conclusive, that EI underreporting is specific to foods and beverages high in energy density (i.e., high in sugar and/or fat). Our work and that of others has shown that dietary misreporting, that is, underreporting or overreporting, may result in spurious statistical associations of dietary variables with body mass index (BMI) and chronic disease risk factors, which in turn may lead to incorrect conclusions about potential dietary contributors to overeating, obesity, and other health outcomes. Biomarkers that serve as objective, independent measures of dietary variables thought to be commonly and selectively misreported would help to verify which specific dietary factors are misreported by which individuals. In this response to PAR-07-259, Improving Diet and Physical Activity Assessment, our overall hypothesis is that dietary misreporting is specific to certain types of foods and/or nutrients; in particular, high fat and high sugar foods are underreported, and fruits and vegetables are overreported. We will recruit n=282 ethnically diverse men and women aged 18-65 y and BMI 18.5-40 kg/m2 from the Healthy Purdue population, a university-based healthy lifestyle program with >9000 participants. We will test our hypothesis by assessing novel (urinary sucrose + fructose, plasma dihydrophylloquinone) and established (plasma carotenoids, serum phylloquinone) dietary biomarkers, reported dietary intakes, and their relationships with each other as well as with health outcomes in the total study sample (n=282) compared to the subsample of physiologically plausible EI reporters (target ne120; where, according to previously-establish methodology, an individual's EI is plausible if it is within 11 SD of total energy expenditure measured by doubly labeled water). Additionally, by using information on reported intake and biomarkers in the plausible subsample we will develop and test a system for correcting misreported dietary intake variables in physiologically implausible reporters. The results of this study are expected to improve our understanding of the nature of reporting error in dietary assessment methodology, and ultimately help clarify relationships between different components of dietary intake and health outcomes. PUBLIC HEALTH RELEVANCE: Two-thirds of the US population is overweight or obese, and therefore at risk for associated chronic diseases including diabetes, heart disease, or certain types of cancer. Determining the relative importance of proposed dietary contributors to these conditions is difficult because people's self-report of what, how much, and how often they consume certain types of foods is often inaccurate. Our proposal to measure objective biological indicators of dietary intake should improve dietary assessment results and lead to greater knowledge about specific dietary contributors to weight gain and chronic
Project Description: No Activity Completed
Infrastructure Description: N/A
Jobs Summary: N/A (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 24, 2009. Help expand these official descriptions using the wiki below.