Grant: $173,156 - National Institutes of Health - Sep. 25, 2009
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Award Description: This application is submitted in response to an RFA-OD-09-004 entitled 'Recovery Act Limited Competition for NIH Grants: Research and Research Infrastructure 'Grand Opportunities' (RC2)' and addresses the NIDCR Area of Scientific Priority 'Genome-wide Studies in Craniofacial, Dental, and Oral Conditions'. Periodontitis is a prevalent, complex dental disease characterized by loss of periodontal attachment and oral bone. However, specific genes underlying susceptibility to periodontitis are still largely unknown. Genome-wide association (GWA) analyses represent a powerful strategy for dissection of genetic etiologies of common human diseases, but this powerful approach has not yet been applied to genetic analyses of periodontitis. Our general hypothesis is that periodontitis risk genes can be detected with a powerful GWA study (GWAS). For this goal, we will achieve the following two Specific Aims: Aim 1: To perform a powerful and efficient GWAS (using the latest GWA array of SNPs and copy number variants (CNVs)) in 2,001 unrelated Caucasian subjects, including 1,000 subjects having severe periodontitis (cases) vs. 1,001 subjects with no or only mild periodontitis (controls). The subjects were selected from 3 cohorts recruited at the State University of New York at Buffalo. Aim 2: To replicate/validate the top 0.5% (~5,000) most significant findings (SNPs/CNVs) identified in Aim 1 in two independent cohorts, one containing 4,012 Caucasians and another one ~1,000 African Americans. Joint analysis of data from Aims 1 and 2 will also be performed to increase the power of identifying markers important to periodontitis. The subjects were selected from the Dental ARIC population. Identifying the risk genes for periodontitis is important for 1) gaining insights into the fundamental molecular mechanisms for the disease; 2) discovering new pathways and targets for therapeutic cures for the disease; and 3) identifying subjects genetically susceptible to periodontitis so that future preventions and interventions can be targeted to and based on an individual's specific genotypes.
Project Description: This application is submitted in response to an RFA-OD-09-004 entitled 'Recovery Act Limited Competition for NIH Grants: Research and Research Infrastructure 'Grand Opportunities' (RC2)' and addresses the NIDCR Area of Scientific Priority 'Genome-wide Studies in Craniofacial, Dental, and Oral Conditions'.
Jobs Summary: Project just awarded; being setup in PeopleSoft. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 25, 2009. Help expand these official descriptions using the wiki below.