YALE UNIVERSITY
Grant: $498,468 - National Institutes of Health - Sep. 28, 2009
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Award Description: This application addresses the broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge topic, 03-MH-101: Biomarkers in Mental Disorders and is entitled: Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Contribute to High Risk in Bipolar Disorder. The proposed study addresses a critical gap in knowledge that could have a major impact on progress in suicide prevention: identification of neural circuitry biomarkers of adolescent and young adult suicidality and the biological and environmental factors that contribute to their development. Each year, over one million individuals lose their lives to suicide worldwide, including more than 32,000 Americans. For adolescents and young adults, suicide is the 3rd leading cause of mortality. Suicide is preventable. The critical issues in its prevention are its early identification and addressing its risk factors; however, biomarkers for adolescent and young adult suicidality have not been identified. The development of biomarkers of suicide in adolescents and young adults is especially critical, as it could contribute not only to prevention of suicide in this age group, but evidence suggests that antecedents to suicide through adulthood are present in childhood and adolescence during which biological and environmental factors alter the development of neural circuitry leading to lifelong increases in suicide vulnerability. The proposed study brings together a new multidisciplinary team of investigators to focus on the identification of neural circuitry biomarkers of adolescent and young adult suicidality. This includes investigators with expertise that spans basic molecular neuroscience, genetic, development, child and adult psychiatry, neuropsychology and neuroimaging study. Adolescents and young adults with bipolar disorder (BD) with a history of suicide attempts will be compared to adolescents and young adults with BD without a history of suicide attempts, as well as adolescents and young adults who do not have a psychiatric disorder. Suicidality in BD will be the focus of this project, initiating this new program of research in adolescent/young adult suicide, as BD is associated with one of the highest rates of suicide from amongst psychiatric disorders and is associated with a high rate of suicide in adolescents and young adults. Thus, study of development of suicide in BD could lead to the development of biomarkers associated with high risk for suicide and aid the development of prevention strategies that could be targeted to this high-risk group.
Project Description: See Award Description
Jobs Summary: None (Total jobs reported: 0)
Project Status: Not Started
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