Grant: $47,210 - Department of Health and Human Services - Jun. 4, 2009
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Award Description: Investigating host genetic polymorphisms contributing to influenza virus disease
Project Description: The Aims of the project are to: Aim 1. Map genetic loci associated with influenza A virus susceptibility and pathogenesis in the Collaborative Cross, and Aim 2. Characterize the effects of Mx1 on IAV infection in a set of genetically diverse mouse lines. We have made significant progress toward the completion of Aim 1 in that we have recently completed the phenotypic analysis of approximately 150 pre-CC mouse lines for susceptibility to influenza virus-induced disease and viral replication within the lungs. The final phenotype, which is quantifying virus-induced pathology within the lungs is, is almost complete. We have also finished genotyping these 150 mice and are currently in the process of finishing the quality controls on the genotyping before starting the analysis to determine whether specific genetic loci associate with each of the phenotypes. With respect to Aim 2, we have preliminary results from a subset of lines that suggests that wild type Mx1's effect on influenza control is influenced by the background genotype of the animal. While some animals with wild type Mx1 are, as expected, highly resistant to influenza, other animals with wild type Mx1 are highly susceptible, suggesting that other genetic determinants can influence the ability of Mx1 to confer protection.
Jobs Summary: This award has allowed us to retain Dr. Martin Ferris as a postdoctoral fellow within the laboratory. Dr. Ferris is a postdoctoral fellow who is receiving extensive training in viral pathogenesis and host genetics and this project is providing Dr. Ferris with salary support that has allowed us to maintain his position and continue his training. (Total jobs reported: 1)
Project Status: Less Than 50% Completed
This award's data was last updated on Jun. 4, 2009. Help expand these official descriptions using the wiki below.