UNIVERISTY OF MISSISSIPPI MEDICAL CENTER
Grant: $489,075 - National Institutes of Health - Sep. 30, 2009
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Award Description: In the work to be supported by this award, we will: 1) Extend the best methodology for imputation to African Americans, producing public-domain software to execute these analyses, validating our methods, and providing a public-domain database of all known polymorphisms and their imputability in African American cohorts; 2) Extend effective CNV data resources and imputation strategies to African Americans, including maps of CNB locations, allele frequencies, and LD properties in African American populations, by integrating data from CARe, the 1000 Genomes Project, and HapMap phase 3; 3) Critically evaluate these methods, resources, and analyses by genotyping SNPs and CNVs in a large African-American cohort, the Jackson Heart Study (JHS), that is also being analyzed in CARe; 4) Use these methods and resources to extend the reach of GWA studies in CARe to far more SNPs and CNVs. To validate our methods, we will genotype in JHS the disease-associated SNPs and CNVs that we discover by imputation in CARe. The work we propose will offer opportunities both to uncover genetic associations of medical importance to African Americans and to demonstrate the efficacy of advanced GWA studies in an admixed population. Although our work emphasizes genetic studies in African Americans, the methods we provide will also improve the reach and quality of GWA studies in all groups whose ancestry derives from multiple continents. Populations like Africans and Europeans that were separated from each other for thousands of generations differ in both the frequency of specific genetic variations and in the relationships these variations have to each other (sometimes called 'linkage patterns'). We will characterize and use the linkage patterns in Americans, most of whom have ancestry from both of these populations. We will develop methods to use information from genetic variants that have a process called 'imputation,' thus providing useful data for literally millions of untyped variants, and greatly increasing the power of efforts to find variants that contribute to human disease.
Project Description: Award was not received until September 30, 2009.
Jobs Summary: no jobs created (Total jobs reported: 0)
Project Status: Not Started
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