Grant: $219,960 - National Institutes of Health - Jul. 14, 2009
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Award Description: Role of the Aryl hydrocarbon receptor (AhR) and RelB during the initiation of dendritic cell differentiation. The present study focuses on a new mechanism of cross talk between AhR and the NF-?B member RelB (alternative AhR/RelB pathway), which suggests an example of how an activated AhR pathway may connect to the NF-?B subunit RelB in order to cooperatively regulate cytokine/chemokine expression as well as differentiation and function of dendritic cells. This work will help to understand the mechanism how environmental toxicants like dioxin or dioxin-like compounds, which activate the AhR, elicit immunotoxic effects and lead to adverse health effects.
Project Description: Role of the Aryl hydrocarbon receptor (AhR) and RelB during the initiation of dendritic cell differentiation
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 14, 2009. Help expand these official descriptions using the wiki below.