UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS
Grant: $235,500 - National Institutes of Health - Sep. 18, 2009
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Award Description: Hypertension is a major cause of morbidity and mortality in the United States, especially in the African American population where the prevalence, consequences, and severity of hypertension are at their highest; making strategies for its control and treatment in this population critical. Although a variety of modifiable and nonmodifiable factors are likely responsible for this, non-pharmacological lifestyle modifications such as changes in diet were shown to have significant blood pressure lowering effects in African Americans. Lifestyle modifications are, however, difficult to sustain in the long-term but if the key components of dietary modification could be provided in a pill form, that was associated with minimal side effects, this would be a major advance in hypertension treatment.
Project Description: The grant investigates whether the DASH diet can be replicated in pill form in a group of patients (African Americans) that have blood pressure that is often sensitive to salt intake. The DASH diet is rich in fruits and vegatables and has a high potassium, magnesium and alkali content. We hope to show that when these micronutrients are administered in pill form they will have effects similar to DASH. It is already established that potassium supplementation alone can reduce blood pressure. As a result we designed a crossover study that compares the effects of potassium chloride to those of potassium magnesium citrate. The grant was just awarded and funding begun on 9/30/2009. We are in the early phases of screening and enrollment at the present time (10/07/09)
Jobs Summary: N/A (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Sep. 18, 2009. Help expand these official descriptions using the wiki below.
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