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DEPARTMENT OF EDUCATION, SOUTH CAROLINA
Grant: $220,198 - National Institutes of Health - Sep. 1, 2009
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Award Description: Candida albicans is the most frequently isolated fungal pathogen of humans. This fungus can switch between three distinct morphological forms: yeast, hyphae, and pseudohyphae. The reversible transition between the unicellular (yeast) and filamentous (pseudohyphal/hyphal) state contributes significantly to the fungal invasion- and pathogenic-process. Thus, there is a great impetus to understand the signals and regulatory pathways that govern the yeast-filament-yeast switch. The long-term goal of this application is to identify the genetic program responsible for stimulating filamentous growth at the in vivo mammalian mucosal surface. This study will generate not only significant insight into understanding the host-fungal pathogen interaction but may also allow the development of new antifungal strategies targeting the morphogenetic- and invasive-processes associated with the pathobiology of an important human pathogen.
Project Description: As defined in the award description field
Infrastructure Description: N/A
Jobs Summary: None to date. (Total jobs reported: 0)
Project Status: Less Than 50% Completed
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