UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS
Grant: $337,374 - National Institutes of Health - Sep. 28, 2009
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Award Description: Inhibition of androgen synthesis is the current treatment of human diseases like prostate cancer and polycystic ovary syndrome. This approach is suboptimal. By defining how the enzyme responsible synthesizes these androgens, we hope to establish new approaches to treatment. Our study will apply to other enzymes that metabolize drugs.
Project Description: Diseases that involve androgen overproduction (such as polycystic ovary syndrome) and diseases that require androgens (such as prostate cancer) can be treated by inhibition of androgen synthesis. Currently available agents are suboptimal. By defining how the enzyme 17-hydroxylase/17,20-lyase makes androgens and how the cofactor protein cytochrome b5 participates in this process, we hope to establish new approaches to treating androgen-dependent human diseases. We will also determine if these principles apply to other similar enzymes that metabolize drugs.
Jobs Summary: N/A (Total jobs reported: 0)
Project Status: Not Started
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