UNIVERSITY OF ARKANSAS SYSTEM
Grant: $345,782 - National Institutes of Health - Jul. 16, 2009
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Award Description: Canonical Transient Receptor Potential Channels and Excitotoxicity Description: The neuronal cell death caused by over exposure to a neurotransmitter called glutamate is a shared event in several neurological diseases, such as epilepsy, stroke and head trauma. New and effective treatment options for these neurological diseases are needed. Detailed knowledge on the mechanism of glutamate-induced neuronal cell death will help to identify new molecular target for drug development. A set of newly discovered ion channels called the canonical transient receptor potential (TRPC) channels may contribute to glutamate induced cell death because they can be activated by a glutamate receptor called metabotropic glutamate receptors. By using both in vitro and in vivo models of epilepsy, this study will determine whether these TRPC channels contribute to the generation of seizure and seizure-induced neuronal cell death. Results from this study will aid future drug development that will provide new treatment options for many neurological diseases.
Project Description: New equipment have been purchased and set up. The new position has been filled and the new hire in currently under training. Experiments in Aim 1 have started and are progressing.
Infrastructure Description: n/a
Jobs Summary: A new research technician position is created and filled with a new college graduate. (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 16, 2009. Help expand these official descriptions using the wiki below.
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