UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS
Grant: $386,002 - National Institutes of Health - Jul. 22, 2009
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Award Description: The identification of a basic-rich motif in the cytoplasmic tail of the CD3e subunit could represent an important breakthrough in our understanding of how complex multi-subunit receptors are assembled, recycled, and signal. Preliminary results demonstrating that this motif can interact with charged phospholipids present at the plasma membrane and in intracellular organelles suggest a novel regulation of TCR-signaling. In fact, the BRS may serve as an ideal target for the strategic intervention of TCR signal transmission during aberrant immune responses.
Project Description: The overall goal of the project is to understand how cellular information is projected from the outside of the cell to the inside. The results from the funded project will greatly advance our understanding of cellular functions. This will have direct applicability in the design of new approaches to control abnormal immune responses in humans susceptible to autoimmune diseases and inflammatory syndromes.
Jobs Summary: The funding of this grant has allowed us to hire 1 new person for the period of thefunding. This individual had no alternate job for the upcoming year. He will now function as a technician and will receive training to become a highly skilled research scientist. The second newly created job was in fact a transfer from a grant that had no more funds. The current grant allowed us to retain a research technician but more importantly advance her training in a new area of reserach. This will open up additional opportunitie for advancing science and developing a highly skilled US lab force for the future. (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 22, 2009. Help expand these official descriptions using the wiki below.
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