Grant: $216,758 - National Institutes of Health - Sep. 15, 2009
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Award Description: This supplement supports an R01 to investigate the neural mechanisms controlling voluntary hand and arm movement in primates. In particular, the supplement is needed to pursue Aims 3-5 of the original proposal. To obtain information important for the use of neural activity to control brain-computer interfaces [BCI] we will systematically investigate the volitional control of identified neurons in different cortical areas using biofeedback training. The correlated responses in other cortical cells and muscles will be documented to determine the extent and variability of correlated activity. Probing the relationship between corticomotoneuronal cells and their target muscles with biofeedback reinforcement of activity patterns will be of particular interest. A novel chronically implanted recurrent BCI will be used to investigate the consequences of directly linking cortical cell activity to stimuli delivered in motor cortex, spinal cord and muscles. An implanted programmable computer, called a Neurochip, will allow long-term monitoring of cell and muscle activity during unrestrained behavior and will be used to implement Hebbian conditioning paradigms that promote cortical plasticity through activity-dependent stimulation. The supplement will pursue less invasive application of this conditioning paradigm by recording and stimulation of the cortical surface. The implanted Neurochip will also be used to test the monkeys' adaptation to continuous operation of recurrent circuits. In this supplement the recurrent BCI will test the feasibility of directly controlling functional electrical stimulation of multiple paralyzed muscles with activity of motor cortex cells.
Project Description: Project recently awarded; no activity to date.
Jobs Summary: Not Applicable this Quarter (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 15, 2009. Help expand these official descriptions using the wiki below.