Grant: $75,869 - National Institutes of Health - Sep. 23, 2009
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Award Description: The original proposal described the production of a series of mutant and chimeric enzymes and their study using kinetics models and stopped flow and steady state kinetics experiments. Ongoing work has revealed that the human signaling ancestors evolved from a common ancestor through a series of coupled frame shift mutations in the control regions. This has allowed the disign of a strategy to produce control element chimera by retracing the evolutionary pathway that lead to the development of modern nitric oxide synthases. This will allow the production of a more informative set of the chimera described in the original proposal. By making chimera which correspond to potential intermediates in the evolutionary pathway, the results will provide insight on the function of individual control elements and on how the different control and kinetics properties of NOS enzymes developed.
Project Description: See Award Description
Infrastructure Description: N/A
Jobs Summary: N/A (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 23, 2009. Help expand these official descriptions using the wiki below.