UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE
Grant: $220,499 - National Institutes of Health - Sep. 30, 2009
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Award Description: This supplemental application is to provide support for an additional postdoctoral research associate to perform work directly related to Specific Aims of the parent project. The overall goal of the parent grant application is to investigate underlying mechanisms by which pregnancy and hypertension in pregnancy affect the cerebral circulation in ways that promote the neurological compliations of eclampsia. Eclampsia is a serious complication of pregnancy that occurs when hypertension during pregnancy develops with neurological complications, including headache, nausea, uncontrolled vomiting, and seizures. The major cerebrovascular changes that occur during eclampsia are similar to hypertensive encephalopathy in which acute elevations in pressure cause autoregulatory breakthrough, decreased cerebrovacular resistance and edema formation. Because of the prominent role of edema formation in mediating the neurologic complications of eclampsia, the long-term objective the parent grant is to investigate the underlying mechanisms by which pregnancy and hypertension during pregnancy affect the cerebral circulation in ways that promote hydrostatic brain edema during increased blood pressure. Our preliminary studies suggest for the first time that pregnancy causes outward remodeling of cerebral arterioles, an effect that likely diminishes small vessel resistance in the brain during acute hypertension. Aim S1 of this supplement is to investigate underlying mechanisms by which pregnancy causes outward remodeling, including the hormone relaxin, known to affect systemic and renal vascular resistance during pregnancy. Aim S2 will use a model of preexisting hypertension or preeclampsia to investigate changes in arteriolar remodeling and cerebral hemodynamics. These Aims are subsets of the Specific Aims of the parent grant application that was funded this past February 1st. This supplement is to therefore accelerate the pace of the parent grant application.
Project Description: See Award Description.
Infrastructure Description: N/A
Jobs Summary: N/A. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 30, 2009. Help expand these official descriptions using the wiki below.
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