Grant: $68,850 - National Institutes of Health - Sep. 21, 2009
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Award Description: Evidence from our ongoing behavioral studies in narcoleptic, orexin receptor deficient mice indicate that increases in cholinergic outflow following the loss of orexin signaling contributes to the disregulation of muscle atonia (cataplexy) which occurs in narcolepsy. An important missing component in our ongoing studies is the ability to concurrently measure EEG/EMG with our video data. We therefore requested ARRA administrative supplement funds to: 1) purchase telemetry equipment for minimally invasive monitoring of EEG and EMG in conjunction with video recordings of orexin receptor knockout mice and 2) hire one full-time team member for 2 years and another full time team member for the second year. Funds were allocated for purchasing part of the requested equipment but not for personell. We therefore plan to use these funds to add the ability to record EEG and EMG activity in conjunction with video. Funds were only made available as of 9/30/09 so we have not yet been able to decide how best to impliment this new functionality. It is anticipated that in the next month or two, we will determine how best to impliment EEG and EMG recording of our mice. This will quickly allow us to accelerate our pace of scientific discovery and increase the depth with which we can analyze the behavioral changes following the loss of orexin receptor signaling.
Project Description: The purpose of this award is to assist our ongoing effort at understanding the neual changes that occur following the loss of orexin neurons in the gensis of the brain disorder narcolepsy. The award provides funds for some equipment that will enable us to better distinguish the states of our experimental mice by monitoring EEG and EMGs. We expect these funds will facilitate our understadning of the brain system changes that produce the disease.
Infrastructure Description: NA
Jobs Summary: N/A (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Sep. 21, 2009. Help expand these official descriptions using the wiki below.