Grant: $283,204 - National Institutes of Health - Jul. 16, 2009
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Award Description: The Acute Respiratory Distress Syndrome (ARDS) is a severe response to a broad range of infectious insults. We believe that the occurrence and severity of ARDS can be mediated by an impairment of the capacity of neutrophils to effectively respond to bacterial infection. This project is designed to prospectively test a mechanism by which viruses dysregulate neutrophil response to bacterial infection, and the clinical impact of this adaptation on ARDS patients. A common response to viral infections is a dramatic increase of Interferon Stimulated Genes (ISG) expression. The Central Hypothesis of this project is that ISG upregulation predicts a transient impairment of the neutrophil response to pathogenic bacteria, resulting in more severe neutrophil-mediated lung inflammation and injury. Results to date have demonstrated a significant increased in 60-day mortality in ARDS patients with high ISG expression. An Administrative Supplement is requested to address two significant gaps within the original proposal. First we will define a global gene expression profile in neutrophils from ARDS patients with high and low ISG expression. We will then use this analysis to create a directed gene expression profile to test the ability of ISG upregulation to predict disease severity and outcome in ARDS. This analysis will allow for a sensitive and objective classification of high ISG expression through an unsupervised clustering analysis. Together, these added aspects will significantly improve our ability to analyze and interpret the results of this project, and accelerate the pace of this research. The proposed work will be conducted by a Level 5 PRA who received his MS degree within the past 3 years, but who has recently lost his job due to the economic downturn.
Project Description: As defined in the Award Description field
Infrastructure Description: N/A
Jobs Summary: Level 5 professional research assistant who received his MS degree within the past 3 years (Total jobs reported: 1)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 16, 2009. Help expand these official descriptions using the wiki below.