Grant: $163,301 - National Institutes of Health - Jul. 17, 2009
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Award Description: Overall Purpose and expected outcome. Funds provided by the Recovery Act will allow us to complete work begun during the past five years in order to advance clinical research on the effects and effectiveness of pharmaceuticals in child health. The funds will provide us with the opportunity to accelerate the pace of science by increasing the understanding of determinants of drug action and effects in pediatrics, to increase the capacity of current research activities, and to create the infrastructure for future research. The funds will also be used to maintain staff, post doctoral fellows and allied personnel. Justification: In 2009 we will complete the following on-going approved: 1. Study 10824 Antimicrobial pharmacokinetics in high-risk preterm infants (expected enrollment, 30-40 infants); 2. Studies 10824 & 10862 Micafungin PK/safety studies in infants and young children(expected enrollment, 10-12 patients); 3. Study 10934 PK of meropenem in infants (expected enrollment, 5-7 patients); 4. Study 10924 Oseltamivir PK in pregnant and post-partum women (expected enrollment, up to 40 patients);
Project Description: The Dallas PPRU is a combined effort between UT Southwestern Medical Center at Dallas, Children's Medical Center and Parkland Health and Hospital System. We are currently conducting studies in drug metabolism, PK , safety and effectiveness of new drugs and drugs already on the market that are necessary for FDA approval for use in children. The overall purpose of this award is to faciliate and improve drug treatment in children. Our major efforts especially recently, have focused on developing and supporting investigator-initiated protocols that would inlcude other centers from the Network or pilot projects that are being conducted in Dallas. We tried to initiated collaborative studies with the OPRU (U Pittsburgh, McGee Womens? Hospital, Dr. Richard Beigi) and our obstetrics group at UTSWMC at Dallas. The OPRU centers were unable to participate because of protocol items that was not acceptable to those centers.The Oseltamivir study is being conducted at parkland Health and Hospital Center with our obststrical colleagues.Studies are still open to enrollment. No data has been analyzed or published.
Jobs Summary: N/A (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 17, 2009. Help expand these official descriptions using the wiki below.