TRUSTEES OF INDIANA UNIVERSITY
Grant: $76,755 - National Institutes of Health - Sep. 17, 2009
No votes have been cast for this award yet
Join the conversation: Post a comment about this award
Award Description: This proposal is for a Recovery Act administrative supplement. It is proposed to appoint a new postdoctoral fellow and thereby stimulate the economy by enabling the hiring of additional staff. The supplement also will accelerate the progress and expand the goals of this project consistent with the NICHD priority to use Recovery Act funds for Developmental Biology and Perinatal Medicine, including basic research on the biochemical, molecular biology, genetic, and cellular mechanisms of early development. The long term goal of this research program is to understand the mechanisms that underlie human pituitary development and to apply that knowledge to the prevention and treatment of pituitary diseases. The pituitary gland secretes hormones that are critical for many aspects of human development and physiology, including growth, reproduction, the stress response, metabolic homeostasis, and lactation. Diseases involving pituitary dysfunction can involve severe syndromes affecting many systems. During embryogenesis, the actions of transcription factors, such as the LHX3 protein, govern the establishment of the hormone-secreting pituitary cell types. This laboratory and others have described that mutations in the LHX3 gene cause pediatric combined pituitary hormone deficiency diseases and nervous system problems. The biochemical mechanism by which proteins such as LHX3 exert their functions is poorly understood. This project tests hypotheses involving the mechanism of LHX3-associated hormone deficiency diseases and the proposed postdoctoral fellow will accelerate the progress and expand the goals of the project, especially improving our ability to analyze a mouse model of pediatric combined pituitary hormone deficiency, allowing molecular and cellular characterization of the disease symptoms and progression, an approach that is not possible in the patients.
Project Description: This proposal is for a Recovery Act administrative supplement. It is proposed to appoint a new postdoctoral fellow and thereby stimulate the economy by enabling the hiring of additional staff. The supplement also will accelerate the progress and expand the goals of this project consistent with the NICHD priority to use Recovery Act funds for Developmental Biology and Perinatal Medicine, including basic research on the biochemical, molecular biology, genetic, and cellular mechanisms of early development. The long term goal of this research program is to understand the mechanisms that underlie human pituitary development and to apply that knowledge to the prevention and treatment of pituitary diseases. The pituitary gland secretes hormones that are critical for many aspects of human development and physiology, including growth, reproduction, the stress response, metabolic homeostasis, and lactation. Diseases involving pituitary dysfunction can involve severe syndromes affecting many systems. During embryogenesis, the actions of transcription factors, such as the LHX3 protein, govern the establishment of the hormone-secreting pituitary cell types. This laboratory and others have described that mutations in the LHX3 gene cause pediatric combined pituitary hormone deficiency diseases and nervous system problems. The biochemical mechanism by which proteins such as LHX3 exert their functions is poorly understood. This project tests hypotheses involving the mechanism of LHX3-associated hormone deficiency diseases and the proposed postdoctoral fellow will accelerate the progress and expand the goals of the project, especially improving our ability to analyze a mouse model of pediatric combined pituitary hormone deficiency, allowing molecular and cellular characterization of the disease symptoms and progression, an approach that is not possible in the patients.
Jobs Summary: Not Started (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 17, 2009. Help expand these official descriptions using the wiki below.
No comments have been added for this project.