Grant: $276,813 - National Institutes of Health - Aug. 12, 2009
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Award Description: The proposed work represents an entirely unique area of kidney research that has not been previously interrogated in either the laboratory or the clinic. By investigating a novel SERM of which level rise progressively with age, this proposed project has the potential to establish novel therapeutic approaches for renal disease including hypertension, nephrolithiasis, and osteoporosis.
Project Description: A research technician has been hired to assist with the experiments in Dr. Umetani's project. The UT Southwestern O'Brien Kidney Research Core Center (NIH 5P30DK079328) provides core facilities and a pilot and feasibility grant program that support kidney research conducted at UT Southwestern and affiliated institutions in Texas. The administrative supplement enhances the capabilities of the Center by expanding the Pilot & Feasibility (P&F) grant program. With this ARRA award, the P&F program has been expanded to support two additional awards of $42,145 this year and again next year: Mishihisa Umatani, Ph.D., UT Southwestern, Project Title: Modification of Kidney Function by 27-Hydroxycholesterol. The goal of Dr. Umatani's proposal is to test the hypothesis that 27-hydroxycholesterol alters renovascular function and mineral homeostasis regulated by estrogen. By investigating this cholesterol metabolite, this project has the potential to identify novel therapeutic approaches for renal disease including hypertension, nephrolithiasis, and osteoporosis. Dr. Umatani's award was recently set up and is actively being utilized to begin research on his project. John Wallingford, Ph.D., UT Austin, Project title: PCP Signaling in Kidney Development and Disease. The goal of Dr. Wallingford's proposal is to study the role of the planar cell polarity protein, fuzzy, in mammalian kidney development and cystic disease. Dr. Wallingford's award is currently being processed as a subcontract between UT Southwestern and UT Austin and is anticipated to be executed within the next few weeks at which point the research can begin.
Jobs Summary: N/A (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Aug. 12, 2009. Help expand these official descriptions using the wiki below.