Grant: $88,366 - National Institutes of Health - Sep. 14, 2009
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Award Description: This K08 Award focuses on the role of Extracellular matrix metalloprotease inducer (EMMPRIN or CD147) as a tumor cell surface molecule that promotes tumor-stromal interactions in head and neck squamous cell carcinoma (HNSCC). As outlined in the first two specific aims of this award, we have successfully characterized the critical role of CD147 in vitro and in vivo in multiple publications [1-4]. Specific Aim 3 seeks to ¿Identify stromal genes that represent a host response to HNSCC.¿ We have previously identified important elements of the stromal response [5-7], and seek additional support to accelerate understanding of the stromal response to tumor cell derived CD147. We present new evidence that CD147 upregulates interleukin-1ß (IL-1ß) which promotes angiogenesis directly and also stimulates other pro-tumorigenic cytokines. Based on these recent findings, this supplement is intended to establish upregulation of IL-1ß as a mechanism by which CD147 promotes HNSCC tumor growth. We hypothesize that CD147 promotes the aggressive phenotype by inducing expression of IL-1ß. The supplemental award would be used to hire technical help to pursue new evidence from our lab that tumor cell derived CD147 upregulates IL-1ß in stromal cells. The successful completion of the experiments described in this application will elucidate the role of CD147-mediated IL-1ß in promoting tumor growth and metastasis.
Project Description: See Award Description
Jobs Summary: Not Started (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 14, 2009. Help expand these official descriptions using the wiki below.