Grant: $218,250 - National Institutes of Health - Jul. 17, 2009
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Award Description: Prostate cancer is the second most common form of cancer in American males. Genotoxic agents, such as ionizing radiation, ultraviolet light, and oxidizing compounds that are generated in normal cellular processes, can damage DNA and are a major cause of cancer. Cells respond to these genotoxic stressors by inducing gene expression and mobilizing proteins to induce DNA repair for cell survival or to trigger pathways that lead to cell death thereby eliminating a potentially cancerous cell. Deformed Epidermal Autoregulatory Factor-1 (DEAF-1) is a protein increased in response to genotoxic stressors and can regulate gene expression and may facilitate cell death. The proposed studies model genotoxic stresses that are naturally occurring in cells and produced by chemotherapeutic agents used in treating cancer. We hypothesize that protein modifications of DEAF-1 will regulate its subcellular localization and interaction with protein partners, which will in turn determine the balance between cell survival and cell death. The results of these studies may give mechanistic insights into additional targets for the treatment of prostate and other cancers.
Project Description: This quarter, one student has been recruited and hired to work on the project. The student have begun their training in maintaining human cells in culture and testing various compounds. We have purchased some of the supplies that are needed for the project and replaced a refrigerator/freezer that died.
Jobs Summary: NA (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 17, 2009. Help expand these official descriptions using the wiki below.