Grant: $1,410,653 - National Institutes of Health - Jul. 27, 2009
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Award Description: DESCRIPTION (provided by applicant): The goal of the proposed BRP is to make wireless neural interface technology a turnkey technology that can be disseminated to the neuroscience and clinical research communities, that will generate validation data for use in an FDA IDE application and that will eventually become the nucleus for a first generation of wireless interfaces for research and acute and chronic clinical and therapeutic use. In order to achieve this goal, we will 1) refine our recently developed and demonstrated wireless neural interface technology, focusing on making smaller, safer and more capable VLSI for signal processing and telemetry in real world environments, 2) develop next generation system integration and biocompatible encapsulation for chronic use, which includes the development of novel Au-soldered lid based system integration concepts for improved reliability, long term stability and increased fabrication yield, and in vitro procedures and setups to test the long term encapsulation of the lids and seals, 3) provide a detailed in vivo validation of wireless recording and stimulation systems as an initial body of data for FDA IDE applications, and 4) implement regulatory documentation and the Quality Systems required by the FDA that will enable transferring the technology into human clinical testing and experimentation, and finally disseminate the integrated neural interface and Utah wireless technology to neuro-engineers and basic systems neuroscientists working in the fields of basic and applied neuroscience. This highly interdisciplinary research will be carried out in the partnership of worldwide renowned expertise in micro systems and integration technology, VLSI, and neurophysiology at the University of Utah, Stanford University, Fraunhofer Institute for Reliability and Microintegration, Ripple LLC., Second Sight Medical Products Inc., and I2S Micro Implantable Systems. Partnerships with commercial partners such as I2S and Second Sight will help alignment of market needs and research efforts, accelerate the transfer to market and benefit from their regulatory expertise. I2S will participate in the consortium providing solutions for co-funding through company's internal fund. PUBLIC HEALTH RELEVANCE: Wireless stimulation and recording neural interfaces with a high number of channels will allow applied and basic neuroscientists to conduct their electrophysiological experimentation in freely behaving animals, which will serve as basic study prior to application in patients with neurological disorders or prosthetic needs to restore disabled sensory and motor functions. Eventually, chronically implantable, wireless neural interfaces will allow long term clinical and therapeutic use for patients, eliminating tethering and friction forces and risk of infection associated with using a bundle of cables, and allowing more convenience in movement and minimal aesthetic disturbance to the patients.
Project Description: SEE AWARD DESCRIPTION
Jobs Summary: Job Titles: Administrative Assistant;Associate Professor;Graduate Research Assistant;Lab Aide;Lab Specialist;Lab Technician;Post Doctoral Fellow (E);Research Assistant Professor; (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 27, 2009. Help expand these official descriptions using the wiki below.