Trustees of The Unversity of Pennsylvania
Grant: $526,062 - National Institutes of Health - May. 5, 2009
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Award Description: Despite a reduction in the incidence of HIV-associated dementia (HAD) in the era of Highly Active Anti-Retroviral Therapy (HAART), the prevalence of HAD is increasing, as is the frequency of minor cognitive diagnoses in HIV-positive patients. Although HAART is neurotoxic in both the peripheral nervous system and cultured neurons, the contribution of HAART to HIV-associated neurocognitive disorders is unknown. We hypothesize that HAART compounds induce neuronal toxicity both directly and indirectly (e.g. alteration of macrophage function), and that these mechanisms are mediated by cell-specific activation of stress responses that differ among classes of HAART compounds. This proposal aims to investigate the cellular mechanisms triggered by the different classes of HAART drugs, in both neurons and macrophages, which is crucial for guiding the design of new drugs and the assembly of combinatorial anti-retroviral therapies that minimize neurological impact.
Project Description: As defined in the Award Description Field
Jobs Summary: This project has 1 jobs created and 5 jobs retained among the positions are RESEARCH SPECIALIST A, ASSOC PROFESSOR A, POST-DOCT. RESEARCHER, TEMP EXTRA PERSON. (Total jobs reported: 1)
Project Status: Less Than 50% Completed
This award's data was last updated on May. 5, 2009. Help expand these official descriptions using the wiki below.
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