Grant: $104,716 - National Institutes of Health - Aug. 15, 2009
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Award Description: Pain is one of the most costly and pervasive public health problems threatening the United States. While ethnic disparities in pain and its treatment have been reported, the influence of ethnicity on responses to analgesics has received scant attention. In the currently funded study (NS55094), a common acute clinical pain model is used to identify and characterize psychosocial, physiological and genetic factors that contribute to ethnic group differences in pain perception and analgesia. Aim 1 will determine ethnic group differences in perceptual and physiological responses to acute post-operative pain and examine how those are related to genetic, pre-operative psychophysical and psychosocial factors. Aim 2 will determine ethnic differences in opioid analgesia and side effects and examines genetic, pharmacokinetic (PK), pharmaco-dynamic (PD), and psychosocial factors that explain group differences in analgesic responses. In response to NOT-OD-09-056, Notice of Availibility of Recovery Act Funds for Administrative Supplements, this supplement project aims to: (1) Create employment through three positions (e.g. full time, increase of half time position to full time, a contractural position for specialized technical skills); (2) Increase the tempo of scientific discovery by including additional minorities in recruitment, thus also making the findings more applicable across populations; (3) Advance the pace of the parent grant by engaging in rapidly developing genetic and PK/PD technology and also stimulating biomedical economic growth through use of supplies and equipment; (4) Achieve the K01 training plan goals by moving the PI closer to scientific independence by accomplishing recruitment, manuscript production and completing an R01 submission; (5) Solidify a strong investigative team for longevity and growth toward novel scientific discovery and increased presence in the local, academic and research communities; and (6) Grow investigation in translational science of pain through enhanced collaborations and advance the tempo of science to reduce health disparities in clinical pain through the development of interventions designed to improve acute pain and enhance analgesic response for improved quality of life across ethnic groups for those who receive suboptimal pain care.
Project Description: In accordance with the announcement and the intentions of the Recovery Act, this current proposal aims to accelerate the tempo of scientific research in several ways. First, this project aims to advance the primary project and recruitment goals of the parent K01. Second, this project proposes creation of two professional positions, one full time and the other to convert a half time position to full-time, and plus it will contract for additional laboratory technical work. Third, through increased specialized analyses, this proposal is supporting the biotechnical industry through purchase of laboratory supplies and equipment usage. Fourth, due to greater subject burden than originally anticipated, we have increased the reimbursement to be commensurate with other comparable studies, and thus funding is used for subject payments. This allows for immediate, expendable income for our research participants in the community. Many of the study participants indicate that they would otherwise not be able to afford the surgery without the supplemental income provided by this study. Through subject reimbursement, we are also indirectly supporting clinical operations, the clinic staff, plus the biomedical industry that supplies the surgeries. In addition, a large percentage of our study sample comes from lower SES or under-served populations, and research participants have reported that the reimbursement allows them to meet important financial obligations (e.g. children?s medication, food), thus creating stimulus of finances in the local economy. Continuing the parent study has scientific merit to learn important aspects of factors contributing to ethnic differences in pain and analgesic response, to provide financial benefit to its participants and the community, for additional analyses to increase scientific discovery, to share knowledge with clinical communities and build collaborations across disciplines to expand and advance science.
Jobs Summary: payroll not yet distributed to project (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Aug. 15, 2009. Help expand these official descriptions using the wiki below.