Grant: $394,800 - National Institutes of Health - Aug. 1, 2009
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Award Description: The purpose of this award to perform research on streptococci and streptococcal diseases in order to better understand the underlying molecular processes, eventually leading to better design of preventative and therapeutic strategies. Group A streptococci (GAS) are remarkable for the wide range of diseases they cause in humans, their sole biological host. Yet, most infections are mild and involve one of two tissues - the epithelial surface of the throat or skin - giving rise to pharyngitis or impetigo, respectively. A long-term goal is to better understand the distinct pathogenic mechanisms leading to pharyngitis and impetigo. A primary focus of the proposal is the regulation of pili expression in GAS. Significant and meaurable deliverables will include peer-reviewed publication of results.
Project Description: The first quarter focuses on testing environmental conditions that affect pilus gene transcription, mutant generation and characterization, improvements to the animal model, and testing mutants in the animal model. Progress has been made on all items. In addition, data was collected on the behavior of one mutant in the animal model, and the findings are being prepared for submission for publication in a peer-reviewed journal.
Infrastructure Description: NA
Jobs Summary: NA (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Aug. 1, 2009. Help expand these official descriptions using the wiki below.
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