VIRGINIA COMMONWEALTH UNIVERSITY
Grant: $237,862 - National Institutes of Health - Jul. 16, 2009
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Award Description: The supplement request is still within the scope of the approved project to further clarify how propyl hydroxyase domain (PHD) enzymes participate in the regulation of salt adaption of the kidneys. High salt diet inactivates PHD in the kidney, which increases the expression of some protective genes and related factors, and thereby increases urinary salt excretion. If this enzyme is not working properly, excessively eaten salt cannot be removed, and salt-sensitive high blood pressure occurs. Clarification of this mechanism will ultimately suggest new therapies for treatment of high blood pressure. This protocol will further explore the mechanisms involved in high salt-induced PHD2 inhibition in the renal medulla and test the hypothesis that high salt intake inhibits PHD expression through activation of heat shock protein (HSP) 70, which decreases PHD2 mRNA levels via binding to toll-like receptor (TLR) 4. We will first explore the role of HSP 70/TLR4 pathway in renal medullary PHD2 changes in response to high salt intake; we will then determine the effect of inhibition of HSP70/TLR 4 pathway in the renal medulla on renal sodium excretion and blood pressure after high salt challenge.
Project Description: Progress is being made towards all aspects of the project as described in the Award Description field
Jobs Summary: Not applicable (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 16, 2009. Help expand these official descriptions using the wiki below.
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