Grant: $561,382 - National Institutes of Health - Sep. 4, 2009
No votes have been cast for this award yet
Award Description: Goals: The parent award addresses the epigenetic basis whereby developmental exposures to natural or environmental estrogens predispose to prostate carcinoma with aging. Our working hypothesis is that natural or environmental estrogenic exposures at environmentally relevant doses during developmental critical periods may be a predisposing factor to prostatic carcinoma in the aging male and provide a fetal basis for this adult disease. The objectives of the parent award are to delineate the impact of early BPA exposures on prostate carcinogenesis, to characterize in detail the prostatic gene methylation and transcriptional alterations that result from early–life estrogenic exposures and to determine if there is an epigenetic basis for estrogenic predisposition to carcinogenesis. With supplemental funding for additional research staff, we hope to leverage opportunities that will increase the value of the parent NIEHS award, R01 ES015584.. Importantly, this additional work is within the scope of the aims approved in the parent grant. Specific Aim 1: Perform pharmacokinetic analysis for serum BPA levels following neonatal BPA exposure to rats, comparing oral administration to subcutaneous routes of exposure. Specific Aim 2: Accelerate research pace and increase animal numbers in the neonatal BPA dose-response study and prostate cancer susceptibility Specific Aim 3: Use Nimblegene rat promoter arrays for genome-wide analysis of prostate gene methylation alterations induced by neonatal BPA exposure.
Project Description: The work has not yet been intiated since the accounts are being establsihed. Hires and lab work will occur in Quarter 2.
Jobs Summary: There will be 1.5 FTE created at UIC, the primary site and there will be an additional 0.85 FTE retained at the subcontract site. At the University of Illinois at Chicago, the jobs are as follows: 1) 1.0 FTE as a research laboratory technician, 2) 0.5 FTE as a scientific postdoctoral fellow. Both of these positions are primary research and laboratory jobs. At present, these hires have not yet occured. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 4, 2009. Help expand these official descriptions using the wiki below.