JOHNS HOPKINS UNIVERSITY
Grant: $16,400 - National Institutes of Health - Jul. 14, 2009
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Award Description: This supplement supported the hiring of two undergraduate students for the summer. Both students contributed to the progress of the project by processing brain tissue of rats that had undergone multi-day peripheral injections of gut peptides or multi-day jejunal infusions of specific nutrients to investigate if the manipulation-induced decreases in food intake and body weight are mediated by central orexigenic and/or anorexigenic neuropeptides. The students used RT-PCR, in situ hybridization and immunohistochemical techniques to assess alterations in hypothalamic and brainstem gene/protein expression.
Project Description: The parent grant supports work examining the actions of gut peptides in feeding control and how their effects are centrally mediated. Specific aims focus on the actions of leptin in affecting the saliency of gut feedback signaling and on how different gut peptides interact when given in combination. A final set of experiments begins to model aspects of bariatric surgery by examining how jejunal nutrient infusions, the site of the reconnection in gastric bypass, affect food intake and body weight.
Infrastructure Description: N/A
Jobs Summary: Two undergraduate student positions were created by the prime recipient. (Total jobs reported: 2)
Project Status: More than 50% Completed
This award's data was last updated on Jul. 14, 2009. Help expand these official descriptions using the wiki below.
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