Case Western Reserve University
Grant: $314,000 - National Institutes of Health - Sep. 22, 2009
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Award Description: This award was made to fund two pilot projects for two years at $50,000 a year. These pilots will advance our understanding of the role of role of hypoxia in the etiology, pathogenesis, and treatment of cancer and the growth and migration of cancer stem cells, leading to further advances and collaborations. Areas of potential interest include: 1) the role of hypoxia-mediated anti-angiogenic therapies that target cancer stem cells 2) investigation of disease specific tumor stem cells and creation of iPS from cancer stem cells 3) investigations into hypoxia-activated tumor-selective therapy, including pro-drugs, 4) investigations into the role of HIF-1 in modulating intracellular pH, metabolism, cell invasion, autophagy and cell death, and 5) investigation into hypoxia’s role in maintaining the stem cell phenotype.
Project Description: The overall purpose of this award is to expand research into cancer stem cells. Cancer stem cells are tumor cells that self renew and propagate tumors phenotypically similar to the parental tumor. These studies will produce additional knowledge into the etiology, pathogenesis, and treatment of cancer and the growth and migration of cancer stem cells, leading to further advances and collaborations and development of novel therapeutics. A description of the research proposals sought for funding under this program is being prepared.
Jobs Summary: We expect to create a minimum of 2 FTEs as part of this award. The positions will be for research assistants to conduct the research described in the application. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 22, 2009. Help expand these official descriptions using the wiki below.
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