Grant: $19,829 - National Institutes of Health - Jun. 5, 2009
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Award Description: Role of Phospholipid PI (4, 5)P in Wingless signaling
Project Description: Using a antibody which specifically binds to Phospholipid, PI (4, 5)P our earlier results showed that PI (4, 5) expression pattern is similar to the expression of Wingless protein in the eye imaginal disc. During the current duration of the grant, we extended this observation and showed in mutliple developmental systems during Drosophila Imaginal disc development, we see a correlation between the expression of Wingless protein and the accumulation of PI(4,5)P. Furthermore, gain and loss of function studies show that increase in the levels of Wingless signaling results in an increase in the accumulation of PI(4, 5)P while loss of wingless signaling results in a loss of PI(4, 5)P. These observations suggest a direct link between Wingless signaling and PI(4, 5)P accumulation. In all of the above mentioned studies we always observed increase PI(4, 5)P to be localized to the nucleus. To investigate the possible role of this phospholipid in the regulation of Wingless target genes, we used the Drosophila wing imaginal disc as a model, in which Wg functions in the transcriptional up regulation of Distalless in a graded fashion. Loss of Wg signaling which results in the loss of PI(4, 5) accumulation also results in loss of Distalless expression. Our future studies will focus towards identifying the molecular pathway by which PI(4, 5) regulates Distalless expression downstream of Wg signaling.
Jobs Summary: UCLA is a world-class educational institution in the midst of an unprecedented financial crisis that threatens our mission to provide education, research and public service benefiting millions of people. ARRA funding to the University has enabled the creation and retention of jobs to support vital scientific research and training activities that would otherwise be severely constrained or eliminated through budget cuts. The type(s) of jobs created and retained by this ARRA-fund award includes: Scientific/Technical Professionals and Staff positions, such as Researchers, Post-Docs, Graduate Student Researchers, Project Managers and Statisticians. (Total jobs reported: 0)
Project Status: More than 50% Completed
This award's data was last updated on Jun. 5, 2009. Help expand these official descriptions using the wiki below.