THOMAS JEFFERSON UNIVERSITY
Grant: $374,260 - National Institutes of Health - Jun. 15, 2009
No votes have been cast for this award yet
Join the conversation: Post a comment about this award
Award Description: The long-term goal of this project is to shed light on the molecular mechanisms that govern the function and regulation of the neuronal somatodendritic A-type potassium current (Isa). Typically, Isa operates in the subthreshold range of membrance potentials and is a pivotal player in the ensemble of active membrane currents that regulate somatodendritic signal integration; therefore, it has a broad impact on the electrical plasticity of the brain.The Kv4 channel complex is the molecular correlate of Isa. This complex includes the KV4 pore-forming a-subunit encompassing three modular domains common to all voltage gated k+ channels: The experimental approach is based on a multidisciplinary research plan that combines electrophysiological, biochemical, molecular and computational methodologies. This work is likely to impact the study of neurological entities possibly linked to the Kv4 channel complex, such as epilepsy, pain plasticity, neurodegenerative disorders, and autism.
Project Description: As described in Award Description.
Jobs Summary: Prime Recipient Created - 1 Doctoral Student; Retained - 1 Professor, 1 Assistant Professor and 1 Research Tech A (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on Jun. 15, 2009. Help expand these official descriptions using the wiki below.
No comments have been added for this project.