Grant: $578,277 - National Institutes of Health - Sep. 1, 2009
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Award Description: 'PURPOSE: The goal of this project is to determine the developmental fate and gene expression of the head surface ectoderm in the absence of the retina. Identification of these genes and developmental processes will lead to the better understanding of eye diseases. ABSTRACT: Development of the vertebrate eye requires a series of developmental events that lead to the formation of the retina and the lens, which are collectively called the eyeball. In addition to the eyeball, eye-associated structures, such as the cornea, lacrimal gland, eyelid and conjunctiva, are made that are required for the proper function of the eyeball. Our long-term goal is to identify developmental steps and molecular events necessary for the correct formation of each individual vertebrate eye structure. In this project, we are focusing on the development of anterior eye structures, with the primary aim to understand lens development. This proposal is a natural continuation of our previous studies investigating the role of the forkhead box-containing gene Foxe3 in lens formation, and the role of the homeobox-containing gene Rx in retinal formation. '
Project Description: As defined in the Award Description field
Jobs Summary: 'RESEARCH INSTRUCTOR 0.63FTE: postdoctoral experience in the area of mouse genetics and developmental biology. Responsible for setting up the genetic crosses for this study, as well as in the analysis of eye development in the mutant mice. In addition, she is actively involved in preparation of all manuscripts resulting from this study. RESEARCH ASSISTANT I 1.0 FTE: performs responsible research work of a complex nature that requires planning, completing, and occasionally supervising limited research projects in accordance with general plans approved by the supervisors. ' (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on Sep. 1, 2009. Help expand these official descriptions using the wiki below.