Grant: $407,500 - National Institutes of Health - Aug. 17, 2009
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Award Description: Title: Mechanism of Retrocorneal Fibrous Membrane Description: During abnormal wound healing, corneal endothelium (the inner layer of the cornea) is transformed into fibroblasts which produce scar tissue (fibrosis) in the otherwise transparent cornea. Such corneal fibrosis blocks light transmittance, leading to blindness. Our goal is to understand the molecular mechanism of endothelial mesenchymal transformation (corneal fibrosis) and to intervene in this abnormal wound healing process
Project Description: The project period start date was September 30, 2009, only one day in this reporting quarter, therefore, we will have an activity report for the next quarter.
Jobs Summary: Doheny Scientist position was retained which entails assisting the principal investigator in conducting research and laboratory activities and highly technical and complex research projects , analyzing research data and is responsible for supervision of laboratory personnel. This position requires experience in all aspects of EMT of corneal endothelial cells, such as p27 degradation, reorganization of actin cytoskeleton, cell migration facilitated by Cdc42, FGF-2 induction triggered by IL-1 Beta, and the IL-1 Beta mediated EMT process. A background in molecular biology and additional training in cell biology is essential for this project. (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Aug. 17, 2009. Help expand these official descriptions using the wiki below.