Grant: $497,270 - National Institutes of Health - Sep. 29, 2009
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Award Description: This application addresses broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic 01-CA-102, The Role of Nutrition in Cancer Biology. Our long term goals are to characterize the role of genomic stability in dietary prevention of cancer and to develop an intermediate bioassay of DNA damage for testing efficacy of dietary agents. These studies will provide proof of principle of this concept and establish the bioassay through study of vitamin D and genomic stability. This project specifically targets the Challenges 'Prevention' and 'Role of Nutrition in Cancer Biology' in the following ways: 1. Focus on normal mammary cells and cancer prevention; 2. Testing dietary vitamin D supplementation in vivo; 3. Development of an intermediate bioassay for testing effects of chemopreventive agents on the DNA damage response; 4. Initiation of a prevention genomic database. People are continuously exposed to environmental agents that can cause genetic mutations and increase the risk of cancer development. Fortunately, healthy tissues can repair the majority of these mutations. Some cells do eventually accumulate enough damage over time that they become cancerous. Based on this paradigm of age-related accumulation of damage, it stands to reason that dietary factors might delay cancer development by maximizing tissue repair processes. In this project we will develop methods to study damage and repair processes in mammary gland, and will perform initial experiments to test whether vitamin D acts to prevent breast cancer via enhancement of cellular protective responses.
Project Description: As defined in the Award Description field
Jobs Summary: Not applicable for this reporting period. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 29, 2009. Help expand these official descriptions using the wiki below.