Grant: $78,500 - National Institutes of Health - Jun. 10, 2009
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Award Description: This application is to find out why kallikreins are regulated and how they exert protective effect against immune nephritis. Finally we will develop a mouse model in which we can control the kallikreins expression specifically in kidney during specific disease development stage by injecting a reagent named tomaxifen. We will evaluate if the targeted gene therapy will be able to prevent or cure the kidney disease caused by lupus, using this mouse model.
Project Description: The current proposal is designed to identify the regulatory elements for the klk upregulation and determine the down-stream molecular pathways related with the enhanced klk expression in kidney tubular cells. A murine model with inducible kidney specific expression of klk will be developed to further assess whether the enhanced klk/kinin signaling in kidney will mediate renoprotection against lupus nephritis induced by Sle1.Sle3 lupus susceptibility loci.
Jobs Summary: MD, PhD, Research Scientist, will perform most experiments in Aim 2 for developing transgenic mouse strain. Reviews and analyzes resulting research data, plans experimental protocol, compiles, writes and submits research results to PI. Research Assistant, will help PI and Research Scientist to carry out the experiments. Plans, coordinates and supervises the research project, performs advanced scientific research work. (Total jobs reported: 2)
Project Status: Less Than 50% Completed
This award's data was last updated on Jun. 10, 2009. Help expand these official descriptions using the wiki below.