Grant: $1,362,108 - National Institutes of Health - Sep. 1, 2009
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Award Description: The experiments in this project are designed to generate improved vaccines against HIV-1 based on recombinant vesicular stomatitis viruses. The vaccine vectors developed in this project will be compared with recombinant RV and NDV vectors generated in projects 1 and 2. Our laboratory has been engaged in research on VSV for over 25 years. A critical outcome of our research is that we have been able to genetically dissociate the ability of the virus to suppress host innate immune responses without compromising the ability of the virus to assemble infectious progeny. The argument is made in this section that we are in a unique position to develop a new generation of VSV vaccine vectors designed to enhance innate immune mechanisms. Such vectors should have greater safety by modifying the determinants of viral virulence and should have greater efficacy due to the enhancement of adaptive immunity by innate immune responses.
Project Description: As described in Award Description.
Jobs Summary: No jobs created or retained yet as project has not started. (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 1, 2009. Help expand these official descriptions using the wiki below.