Grant: $50,054 - National Institutes of Health - May. 29, 2009
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Award Description: The outer membrane (OM) of a Gram negative bacterium is its interface with the outside world. The OM acts as a selective barrier to block harmful substances (such as drugs or viruses) and pass critical nutrients. OM composition is traditionally studied in bulk, measuring averages over large numbers of bacteria. Little is known about OM heterogeneity within the population. In fact, non-genetic variation is certainly present, and would be expected to cause differences in growth and survival at the level of individual cells. This research aims to (1) quantify cell-to-cell variation in OM expression, (2) test several mechanisms by which the population may generate this variation, and (3) measure the contribution of this natural variation to bacterial survival under changing conditions including antibiotic treatment.
Project Description: We have implemented a direct labeling method to analyze the partitioning of specific proteins in the outer membranes of individual cells during bacterial growth.
Jobs Summary: Postdoctoral Fellow (Total jobs reported: 1)
Project Status: Less Than 50% Completed
This award's data was last updated on May. 29, 2009. Help expand these official descriptions using the wiki below.