Grant: $500,000 - National Institutes of Health - Sep. 28, 2009
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Award Description: Peripheral arterial disease (PAD) occurs in 3-10% of the general population and increases to 10-15% in persons over 70 years. Advancements in endovascular therapies for PAD are limited by the lack of a suitable, biocompatible surface for the covering of these blood-contacting devices that lead to thrombosis. The availability of an appropriate, thrombus resistant material for endovascular devices could lead to significant improvements in the over-all mortality and morbidity of PAD. UCLA has developed a unique process that can produce super-hydrophilic and thrombus-resistant thin film Nitinol. It is our hypothesis that this material will be ideally suited for treating PAD without the complications normally associated with current endovascular treatments. We propose to design, fabricate and test a super hydrophilic coated thin film Nitinol (S-TFN) covered stent both in vivo and in vitro for the treatment of PAD.
Project Description: The prevention of endograft thrombosis in the treatment of peripheral arterial disease (PAD) is the primary goal of our project. UCLA has developed a process that can produce super hydrophilic and thrombus resistant thin film Nitinol for covering on stents. It is our hypothesis that this newly developed super hydrophilic surface treated thin film Nitinol (S-TFN) stent can produce endografts which significantly decrease the incidence of thrombosis compared to commercially available expanded polytetrafluroethylene (ePTFE) covered stents used in the treatment of PAD. Our primary aims are to:1) Demonstrate that super hydrophilic thin film Nitinol (S-TFN) is thromboresistant and superior compared to existing treatments, 2) Design, fabricate, and test in vitro prototype S-TFN covered stents for treating peripheral arterial disease, and 3) Demonstrate in vivo short term and long term thromboresistance and patency of the S-TFN covered stents compared to commercially available stents.
Jobs Summary: N/A (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 28, 2009. Help expand these official descriptions using the wiki below.