TRUSTEES OF INDIANA UNIVERSITY
Grant: $1,425,995 - National Science Foundation - Aug. 26, 2009
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Award Description: We propose to improve and greatly enlarge the recently established prototype database for disordered proteins, DisProt. This database provides an essential depository of information about IDPs. Although this database was very recently established, it is already receiving significant usage, with about 4,000 hits each day. Furthermore, UniProtKB/Swiss-Prot reported recently that cross-references to DisProt were added. However, the present version of DisProt was developed only as a prototype. In this proposal, support for this prototype database is requested. The following research goals will be pursued: 1) Design of data flow, database structure and output. 2) Development of data input includes the following steps: Data input using a web-based interface; Data input using automated discovery. 3) Functional annotation and curation which will involve mapping disordered proteins to UniProt database containing all known, published, or translated proteins (including Swiss-Prot, PIR, TrEMBL, PDB, GenPept, and RefSeq entries); propagating relevant annotations from the UniProt and iProClass databases; and performing sequence analysis and manual curation. 4) Development of computational curation system to assist with manual curation. This aim will be achieved via the following milestones: Automated mapping and analysis; Implementation of new curation interface; Annotation propagation and integrity check; Use of other databases; Use of the guided literature searches; Expert consultation. 5) Development of database management system.
Project Description: We propose to improve and greatly enlarge the recently established prototype database for disordered proteins, DisProt. This database provides an essential depository of information about IDPs. Although this database was very recently established, it is already receiving significant usage, with about 4,000 hits each day. Furthermore, UniProtKB/Swiss-Prot reported recently that cross-references to DisProt were added. However, the present version of DisProt was developed only as a prototype. In this proposal, support for this prototype database is requested. The following research goals will be pursued: 1) Design of data flow, database structure and output. 2) Development of data input includes the following steps: Data input using a web-based interface; Data input using automated discovery. 3) Functional annotation and curation which will involve mapping disordered proteins to UniProt database containing all known, published, or translated proteins (including Swiss-Prot, PIR, TrEMBL, PDB, GenPept, and RefSeq entries); propagating relevant annotations from the UniProt and iProClass databases; and performing sequence analysis and manual curation. 4) Development of computational curation system to assist with manual curation. This aim will be achieved via the following milestones: Automated mapping and analysis; Implementation of new curation interface; Annotation propagation and integrity check; Use of other databases; Use of the guided literature searches; Expert consultation. 5) Development of database management system.
Jobs Summary: Director, Scientist/Scholar (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Aug. 26, 2009. Help expand these official descriptions using the wiki below.
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