University of Rochester
Grant: $279,643 - National Science Foundation - Jul. 26, 2009
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Award Description: With this award from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), the Chemistry Department at the University of Rochester will acquire a matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometer for the study of large molecules such as biopolymers, regular polymers and polymer-like materials. The acquisition will be used in a variety of research studies including: a) the study of conformational changes and dynamics of heme proteins; b) exploration of unsaturated, reactive catalytic complexes of iron; c) understanding the principles of molecular recognition that give rise to the structure and function of proteins; d) investigations of the photophysical properties of novel semiconductor nanometer scale materials; e) mechanistic studies of the secondary structure of nucleic acids leading to selective adsorption on surfaces; f) investigations to rapidly predict RNA structure from sequence information; g) studies to obtain molecular mass information on non-volatile ligands to construct natural substances such as apoptolidin and nakadomarin A. MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights on very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules and polymers. This research will have a significant impact in a number of areas, especially chemistry and biochemistry. This instrument will be an integral part of teaching as well as research, including use by undergraduate and high school teachers who participate in summer research programs.
Project Description: This grant is for the purchase of a MALDI-TOF Mass Spectrometer, supports the research of 6-8 faculty with need of mass measurements on sensitive; high molecular weight materials. Evaluation of potential MALDI instruments is nearing completion. It is anticipated that the final order will be placed within the next month.
Jobs Summary: No jobs have been created or retained to date. (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 26, 2009. Help expand these official descriptions using the wiki below.
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