NORTHERN CALIFORNIA CANCER CENTER
Grant: $501,798 - National Institutes of Health - Sep. 21, 2009
33% voted satisfied - 67% voted not satisfied - 3 vote(s) cast
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Award Description: This request for a two-year Administrative Supplement was submitted in response to Notice NOT-OD-09-056, 'Notice of Availability of Recovery Act Funds for Administrative Supplements , for grant U01 CA69417, 'Northern California Collaborative Family Registry for Breast Cancer (PI: Esther M. John, PhD, Northern California Cancer Center, Fremont, CA). The Northern California Cooperative Family Registry for Breast Cancer (NC-BCFR) is one of 6 sites collaborating in the Breast Cancer Family Registry (BCFR), an international consortium established in 1995 that developed the infrastructure and extensive resources to facilitate and expedite a broad spectrum of multidisciplinary research, ranging from studies of the genetics and genetic epidemiology of breast cancer, including gene-gene and gene-environment interactions, to translational studies addressing clinical, behavioral, and preventive aspects of breast cancer. Over 3700 breast cancer families have been enrolled in the NC-BCFR as of October 2009, including over 2700 families from racial/ethnic minority populations. The objectives of this supplement are three-fold: 1) We will expand the on-going recruitment of minority breast cancer families at the NC-BCFR, focusing on cases with triple negative breast cancer (TNBC), a subtype associated with poor outcomes and more commonly found among racial/ethnic minority breast cancer cases and early-onset cases. As in the on-going recruitment of breast cancer families, incident TNBC cases aged <65 years at diagnosis will be identified through the population-based SEER Cancer Registry of the Greater San Francisco Bay area. HER2/neu status was included in the SEER Cancer Registry database beginning in 1999. We propose to recruit all TNBC cases diagnosed between July 1, 2006 and December 31, 2009 who did not otherwise meet the eligibility criteria for inclusion in the NC-BCFR. We will focus the recruitment on the 5 major racial/ethnic groups in the NC-BCFR, including non-Hispanic whites, Hispanics, African Americans, Chinese, Filipinos and Japanese, who speak English, Spanish or Chinese. In total we will contact an estimated 335 TNBC cases and invite them to enroll in the NC-BCFR. We estimate that 250 TNBC cases will be willing to participate and provide information on cancer family history and epidemiologic risk factors, as well a blood sample. As in the on-going recruitment activities, cases will be asked for permission to contact their first-degree relatives and we estimate to enroll about 250 relatives who will complete interviews and provide a biospecimen. All data will be entered and quality-controlled prior to transmission to the BCFR central database. Processing of biospecimens will be performed at Coriell Medical Institute via an amendment of a current subcontract. 2) We wil perform HER2/neu analyses on stored tumor samples for 158 ER/PR negative breast cancer cases and estimate to identify an additional 101 TNBC cases. The laboratory work will be carried out at Stanford University School of Medicine, Department of Pathology, under the supervision Dr. Teri Longacre, Professor of Pathology. 3) HER2/neu analyses will also be performed on stored tumor samples for 210 ER/PR negative cases from the Ontario site of the BCFR. An estimated 170 TNBC cases will be identified. The laboratory work will be carried out in the Department of Pathology and Laboratory Medicine at Mount Sinai Hospital under the supervision of Drs. Frances O’Malley and Irene Andrulis. A subcontract will be established for the performance on this work.
Project Description: Since September 21, 2009, when this supplement was awarded, we have received IRB approval for this project (September 30) and will now move ahead with recruitment of TNBC families.
Jobs Summary: Data and biospecimen collection and laboratory work have not been initiated yet during this first reporting period, as we first had to obtain Institutional Review Board (IRB) approval to initiate this new study component. Preparation of IRB application was done by existing staff, thus no jobs were retained in September 2009. (Total jobs reported: 0)
Project Status: Not Started
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