Grant: $139,452 - Department of Health and Human Services - Jul. 17, 2009
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Award Description: This pre-doctoral training program at the Chemistry-Biology Interface involves 29 training facultyfrom three departments at the University of Minnesota: Chemistry, Medicinal Chemistry, andBiochemistry, Molecular Biology and Biophysics (BMBB). It seeks to provide a research trainingexperience to its trainees that crosses the traditional disciplinary boundaries of Chemistry andBiology. Common research themes include: Biocatalysis and Biomolecular Design (Distefano,Kauzlauskus, Lipscomb, Ohlendorf, Schmidt-Dannert, Wackett, Wagner, Wilmot, York), TherapeuticAgents (Amin, Bernlohr, Distefano, Georg, Hoye, Mansky, Sturla, Tretyakova, Wagner, Xing),Chemistry of Disease (Arriaga, Bernlohr, Mansky, Murphy, Sturla, Tretyakova, Wagner, Walters,Xing), Metallobiochemistry (Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Tolman, Wackett,Wilmot, York), and Bioanalytical/Biophysical (Arriaga, Bowser, Griffin, Haynes, Pierre, Taton,Tretyakova, Thomas, Veglia, Walters). The research groups of the training faculty are all wellsupported and well equipped. There are extensive facilities for peptide and oligonucleotide synthesis,biofermentation, mass spectrometry, X-ray crystallography, NMR, and computation. Support is requested for 8 trainees each year of the program, each to be supported for a two-yearperiod. Prospective trainees will generally have undergraduate degrees in chemistry, biochemistry oroiology. They will be expected to obtain thorough grounding in chemistry, as well as molecularbiology and biochemistry. The particular emphasis of this training program is a focus on researchproblems that address synthetic/mechanistic questions in biological systems, with the goal ofunderstanding and influencing key at the molecular level. The defining characteristic for this trainingprogram will be to allow first-rate students to grow into accomplished professionals both in theirprimary area of interest and in a complementary field. Students will choose from a menu of requiredcoursework in chemistry and biology. In addition, laboratory rotations, a chemical biology colloquium,an annual symposium, journal clubs, and joint group meetings will enrich the graduate experience ofthe trainees.RELEVANCE (Seeinstructions): The CBITG trainers and their trainees collectively carry out research on fundamental questions related tocurrent important problems in public health. These include understanding how cancers are initiated in thecell, how obesity and diabetes develop and how a muscle works, designing and developing new drugs andassay probes against cancer, HIV, and Alzheimer's disease, and understanding how chemicals are brokendown in the environment.
Project Description: As Defined in the award description field
Jobs Summary: NA (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Jul. 17, 2009. Help expand these official descriptions using the wiki below.