UNIVERSITY OF CALIFORNIA, IRVINE
Grant: $132,163 - National Institutes of Health - Sep. 28, 2009
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Award Description: Specific Aims 1A: Identify additional nuclear DNA pathogenic complex I gene mutations. Specific Aim 2A: Isolate additional deleterious mtDNA mutations in mouse cells and introduce those most similar to human pathogenic mutations into the mouse. Specific Aim 1A + 2A: Combine deleterious nDNA gene mutations with mtDNA gene mutations to determine if nDNA and mtDNA mutations can act synergistically to increase the severity of the phenotype.
Project Description: Specific Aims 1A: Identify additional nuclear DNA pathogenic complex I gene mutations. Specific Aim 2A: Isolate additional deleterious mtDNA mutations in mouse cells and introduce those most similar to human pathogenic mutations into the mouse. Specific Aim 1A + 2A: Combine deleterious nDNA gene mutations with mtDNA gene mutations to determine if nDNA and mtDNA mutations can act synergistically to increase the severity of the phenotype.
Jobs Summary: Created: None Retained: None (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Sep. 28, 2009. Help expand these official descriptions using the wiki below.
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