Grant: $96,386 - National Institutes of Health - Aug. 13, 2009
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Award Description: The proposed Administrative Supplement will accelerate the tempo of scientific research and the achievement of additional research objectives by retaining existing and hiring new personnel to work within the scope of the parent grant's Aim 1a: to develop a theory of preadaptation using theoretical population genetics. Specifically, work supported by the Supplement will be used 1) to calculate how much preadapted cryptic variation it is optimal to reveal in terms of adaptive potential at a time of environmental change 2) to predict what proportion of adaptations are expected to have a complex genetic basis by reconciling the improbability of the fixation of a specified adaptation that works only via multiple simultaneous alleles with combinatorial considerations of the very large number of distinct allelic combinations and 3) to predict the evolution of modifiers of the degree of penetrance of 'crypticity' as a consequence both of ongoing selection to mask the deleterious effects of mutation, and of rare bouts of selection when such variation, both deleterious and potentially adaptive, is revealed. Pulic Health Relevance: Common diseases often have a complex genetic basis that is a product of our evolutionary history. Alleles that now contribute to disease may have been 'cryptic' during most of human history, with affects revealed only now in the modern environment. This work will study the basic properties of cryptic stocks of genetic variation.
Project Description: As defined in the Award Description field.
Jobs Summary: Prime Recipient Retained: research intern; Prime Recipient Created: postdoctoral research associate (Total jobs reported: 0)
Project Status: Less Than 50% Completed
This award's data was last updated on Aug. 13, 2009. Help expand these official descriptions using the wiki below.