Grant: $78,340 - National Institutes of Health - Sep. 25, 2009
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Award Description: Purpose of the supplement: The purpose of the supplement award is to upgrade the main X-band EPR instrumentation supporting the parent grant. It is possible to make the upgrade at modest cost because an X-band magnet and power supply exist in my lab as backups and we have an older microwave bridge that can be upgraded with a new Gunn oscillator, and connected to a new high sensitivity resonator. A new PC/Linux workstation will replace the existing SGI that now runs my high frequency (W-band) EPR instrument, allowing one workstation/software package to manage data acquisition and processing at two frequencies, X- and W-bands. These changes will accelerate data acquisition and processing and will allow personnel to gain experience in modern EPR data processing software. All specific aims in the parent project require characterization of the lipoxygenase iron center and/or the relevant properties of new spin labeled derivatives by EPR spectroscopy. Thus, progress toward all specific goals will be accelerated and enhanced. Relation of the supplement to the parent NIH grant: New paramagnetic resonance spectroscopy data acquisition and analysis is applied to determine the active site substrate conformation in lipoxygenase, a key enzyme in inflammatory responses. Implementation plan: The supplement funds will be used for a one-time equipment purchase. The equipment items will be manufactured by Bruker BioSpin Inc and will be installed by Bruker when delivered. The expected time-table is delivery and installation in less than six months. All papers resulting from work on the parent grant will also cite support through this supplement.
Project Description: Not yet started.
Jobs Summary: N/A (Total jobs reported: 0)
Project Status: Not Started
This award's data was last updated on Sep. 25, 2009. Help expand these official descriptions using the wiki below.